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Abstract

Background

The World Health Organization has approved two drugs: Viagra (sildenafil) and Cialis (tadalafil). We conducted a literature search of the English language literature to identify studies that describe the use of erectile dysfunction drugs in Kenya. A literature search of medical journals, medical societies, and online sources was conducted to search the English language literature for all relevant articles published by health professionals and patients, and to identify all publications with relevant clinical data. The primary outcomes of interest were satisfaction and quality of life scores. We then performed a literature search using the Medical Subject Headings (MeSH) Universal ClinicalTrials (). Results were extracted and reviewed using an evidence-based systematic review and meta-analysis methodology. Twenty-one studies (n=12,831) were included in the search. The mean age of participants was 57.0 years (range 21–89 years). Erectile dysfunction was assessed using the International Index of Erectile Function (IIEF), the Female Sexual Function Index (FSD), the Self-Reported Index of Sexual Satisfaction (SFS), the Female Sexual Function domain of the International Index of Sexual Function (FSD), the Female Sexual Function domain of the Female Sexual Function Index (FSD), the International Female Sexual Function Index (FSD IIEF), and the Female Sexual Function Domain of the Female Sexual Function Index (FSD IIEF). The mean number of men of each sex was 5.4 (range 2–8). Seven studies (n=1,076) were eligible. The mean age of participants was 60.1 years (range 18–91 years). The mean number of men of each sex was 3.2 (range 2–6). Erectile function was assessed using the Female Sexual Function domain of the Female Sexual Function Index (FSD IIEF) and the Female Sexual Function domain of the Female Sexual Function Index (FSD IIEF). The mean number of men of each sex was 5.6 (range 2–8). The mean number of men of each sex was 4.6 (range 2–7). The mean age of participants was 52.3 years (range 18–92). The mean number of men of each sex was 3.1 (range 2–7). The mean age of participants was 63.7 years (range 18–93). Erectile dysfunction was assessed using the International Index of Erectile Function (IIEF), the Female Sexual Function Index (FSD), the Female Sexual Function domain of the Female Sexual Function Index (FSD IIEF), the International Female Sexual Function Index (FSD IIEF), the Female Sexual Function Domain of the Female Sexual Function Index (FSD IIEF), and the International Female Sexual Function Index (FSD IIEF). The mean number of men of each sex was 3.9 (range 2–9). The mean number of men of each sex was 3.9 (range 2–7). The mean age of participants was 62.3 years (range 18–93). The mean number of men of each sex was 3.2 (range 2–8). The mean age of participants was 59.6 years (range 18–91). The mean number of men of each sex was 3.3 (range 2–8). The mean number of men of each sex was 3.1 (range 2–8).

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Cialis medicine contains the active ingredient Tadalafil. It belongs to the family known as phosphodiesterase type 5 (PDE 5) inhibitors. It is used to treat erectile dysfunction (impotence) by preventing erectile dysfunction that occurs naturally or is not available with traditional treatment. Erectile dysfunction can be a sign of a growing male health problem, such as diabetes, high blood pressure, high cholesterol, and high blood sugar. This problem can be due to a problem with your blood vessels or nerves. When sexual stimulation occurs, the function of the erectile tissue of the penis becomes up for use. This process results in an erection that is to be stored in a safe place away from moisture and heat. Cialis medicine is used to treat erectile dysfunction (impotence) in men. This medicine works by relaxing the blood vessels in the penis, allowing for increased blood flow and enabling the production of nitric oxide. This medicine does not provide all the benefits of traditional treatment for erectile dysfunction. You need to consult a doctor before taking this medicine if you are allergic to any of the ingredients, or if you have any other medical conditions or are taking any other medicines.

Cialis medicine is a PDE5 inhibitor medication. It is commonly used to treat erectile dysfunction in men. It is commonly used to treat benign prostatic hyperplasia (BPH) by relaxing the bladder and prostate muscles. Cialis works by inhibiting the PDE5 enzyme, allowing the blood vessels in the penis to relax. This allows the blood vessels in the penis to widen and increase blood flow. This allows for better erections. Cialis medicine also has some side effects that may include headache, dizziness, nasal congestion, and indigestion. These side effects are usually mild and temporary. Consult a doctor if they occur. Tell the doctor if you or your partner has any history of heart attack, stroke, or life-threatening irregular heartbeat. Cialis medicine may also increase the risk of getting heart-related conditions, such as a atrial fibrillation. Discuss all your medications and medical conditions with a doctor before using Cialis medicine. A heart attack or stroke is a serious condition requiring immediate medical attention. If you have heart problems, you could get a heart transplant or need emergency medical treatment. Cialis medicine is a PDE5 inhibitor medication used to treat erectile dysfunction in men. It works by preventing the breakdown of a substance in the body, called phosphodiesterase type 5 (PDE5) inhibitors. This allows the blood to flow into the penis when sexual stimulation occurs, which causes an erection. Cialis medicine prevents the breakdown of the substance, PDE5 inhibitors, by the enzyme PDE5. This helps to treat erectile dysfunction in men by preventing the breakdown of PDE5 inhibitors. Cialis medicine is available in tablet form and it is important to take it as directed by your doctor. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. Cialis medicine is usually taken orally 30 to 60 minutes before sexual activity. Take the medicine about 1 hour before sexual activity. Cialis medicine does not protect you or your partner from certain sexually transmitted diseases, such as HIV, hepatitis B, gonorrhea, syphilis, and HIV/AIDS. Cialis medicine is not recommended for women, children, or those with kidney or liver problems. Cialis medicine may also not be suitable for men who are pregnant or may become pregnant. If you are a man who is pregnant or may become pregnant, consult the doctor before taking this medicine. Do not use Cialis medicine if you are breastfeeding or if you are planning to become pregnant. Cialis medicine is not suitable for women, children, or those with a history of severe gastrointestinal (such as indigestion or heartburn) or systemic (such as headache, back pain, nausea, and stomach pain). Cialis medicine is not recommended for women, children, or those with a history of severe kidney or liver problems.

Cialis medicine uses

It works by relaxing the blood vessels in the penis, allowing increased blood flow and enabling the production of nitric oxide. You need to consult a doctor before taking this medicine if you are allergic to any of the ingredients, if you have any other medical conditions, or if you are taking any other medication. Cialis medicine is a PDE5 inhibitor medication used to treat erectile dysfunction (impotence) in men. This allows the blood vessels in the penis to relax and increase blood flow.

Levitra usage has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious effects, seek medical attention immediately.

Common side effects reported from Levitra use include:

  • Headache
  • Upset stomach
  • Heartburn
  • Runny nose

More serious side effects include:

  • An erection that lasts more than 4 hours
  • Loss of vision
  • Blurred vision
  • Dizziness
  • Loss of hearing
  • Difficulty breathing
  • Fainting
  • Swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a serious adverse reaction to this medication and immediately require treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Levitra. Levitra can interact with bodily substances, causing potentially serious adverse reactions.

Do not take Levitra if you take nitrate medications such as isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin. It’s important to inform your doctor if you are taking any form of high blood pressure medication, alpha-blocker medication, prescription antifungals (like fluconazole), or other medications for erectile dysfunction. You should include information about herbal products, especially St. John’s wort.

Do not drink grapefruit juice while taking Levitra.

Talk to your health care provider about safe drinking practices during treatment with Levitra. Levitra can interact with alcohol and cause potentially serious adverse reactions like those above.

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Drug typeAntifungal, Erectile Dysfunction, High Blood Pressure, Lithium
BrandVistaril
Unit dose25 mg, 50 mg, 100 mg
FormCapsule
Brand nameLevitra
Previous treatmentPatient Record
DispositionMedical, Dental, Lab
Current drugOverdosage
Formulary (Treatment)Secondary / Inhalation, Storage
Next higher doseHigher dose
Extended-release (EVRL)Erythema comedosus
Extended-release (ERRl)Erythema multiforme
FormularyOther
ResidueImmunotherapy, Medications
Pre-existingLung, Dental, Other
PregnancyMenopause, Nursing
Drug Class
ManufacturerAveline Pharmaceuticals, Inc.

Cialis is a popular medication used to treat erectile dysfunction and is available in various forms including pills and tablets. It is also available as a chewable tablet, a gel or a liquid suspension that is absorbed into the bloodstream and can be taken orally, a chewable tablet or a chewable tablet that is taken by mouth.

Cialis, also known as Tadalafil, is a phosphodiesterase type 5 (PDE5) inhibitor. It works by increasing blood flow to the penis during sexual stimulation. It is important to note that Cialis should not be taken with nitrates or alpha-blockers, as this combination can cause a dangerous drop in blood pressure.

Cialis can cause side effects, such as headache, dizziness, flushing, nasal congestion, back pain, and muscle pain. These effects are usually mild and temporary, but if they persist or worsen, it is important to seek medical advice. It is important to note that Cialis may have a higher chance of causing priapism (prolonged erection) than other PDE5 inhibitors.